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Structure paper

TitleAntibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.
Journal, issue, pagesActa Crystallogr D Struct Biol, Vol. 75, Page 1003-1014, Year 2019
Publish dateDec 20, 2018 (structure data deposition date)
AuthorsLuptak, J. / Bista, M. / Fisher, D. / Flavell, L. / Gao, N. / Wickson, K. / Kazmirski, S.L. / Howard, T. / Rawlins, P.B. / Hargreaves, D.
External linksActa Crystallogr D Struct Biol / PubMed:31692474
MethodsX-ray diffraction
Resolution1.43 - 2.38 Å
Structure data

PDB-6qb3:
Apo Mcl1 in a complex with a scFv
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6qb4:
Mcl1-scFv complex with an indole acid inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.38 Å

PDB-6qb6:
Mcl1 in complex with a Fab
Method: X-RAY DIFFRACTION / Resolution: 2.24 Å

PDB-6qb9:
Structure of an anti-Mcl1 scFv
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-6qbc:
structure of anti-Mcl1 Fab
Method: X-RAY DIFFRACTION / Resolution: 1.56 Å

PDB-6qf9:
Structure of an anti-Mcl1 scFv
Method: X-RAY DIFFRACTION / Resolution: 1.43 Å

PDB-6qfc:
Structure of an anti-Mcl1 scFv
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-HVN:
3-[3-[[(1~{R})-1,2,3,4-tetrahydronaphthalen-1-yl]oxy]propyl]-7-(1,3,5-trimethylpyrazol-4-yl)-1~{H}-indole-2-carboxylic acid

ChemComp-TLA:
L(+)-TARTARIC ACID

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

Source
  • homo sapiens (human)
KeywordsAPOPTOSIS / Mcl1-scFv complex / Mcl1 / scFv / indole acid / Fab / AZD5991

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