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Title | Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase delta through a Deconstruction and Regrowth Approach. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 11061-11073, Year 2018 |
Publish date | Dec 12, 2018 (structure data deposition date) |
![]() | Barton, N. / Convery, M. / Cooper, A.W.J. / Down, K. / Hamblin, J.N. / Inglis, G. / Peace, S. / Rowedder, J. / Rowland, P. / Taylor, J.A. / Wellaway, N. |
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Methods | X-ray diffraction |
Resolution | 2.03 - 2.48 Å |
Structure data | ![]() PDB-6q6y: ![]() PDB-6q73: ![]() PDB-6q74: |
Chemicals | ![]() ChemComp-HKQ: ![]() ChemComp-HOH: ![]() ChemComp-HKK: ![]() ChemComp-HKN: |
Source |
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![]() | TRANSFERASE / PI3 Kinase Delta / Complex / Structure based design |