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-Structure paper
Title | RASinternal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling. |
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Journal, issue, pages | J. Biol. Chem., Vol. 295, Page 9335-9348, Year 2020 |
Publish date | Jul 8, 2019 (structure data deposition date) |
Authors | Nelson, A.C. / Turbyville, T.J. / Dharmaiah, S. / Rigby, M. / Yang, R. / Wang, T.Y. / Columbus, J. / Stephens, R. / Taylor, T. / Sciacca, D. ...Nelson, A.C. / Turbyville, T.J. / Dharmaiah, S. / Rigby, M. / Yang, R. / Wang, T.Y. / Columbus, J. / Stephens, R. / Taylor, T. / Sciacca, D. / Onsongo, G. / Sarver, A. / Subramanian, S. / Nissley, D.V. / Simanshu, D.K. / Lou, E. |
External links | J. Biol. Chem. / PubMed:32393580 |
Methods | X-ray diffraction |
Resolution | 1.65 - 1.75 Å |
Structure data | PDB-6pq3: PDB-6wgh: |
Chemicals | ChemComp-GDP: ChemComp-MG: ChemComp-SO4: ChemComp-HOH: ChemComp-FLC: ChemComp-GOL: |
Source |
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Keywords | ONCOPROTEIN / KRAS / RAS / Mg / K-RAS / GDP / Internal tandem duplication / ITD / NRAS / N-RAS |