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TitleDiscovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.
Journal, issue, pagesJ. Med. Chem., Vol. 62, Page 10062-10097, Year 2019
Publish dateJul 1, 2019 (structure data deposition date)
AuthorsSelnick, H.G. / Hess, J.F. / Tang, C. / Liu, K. / Schachter, J.B. / Ballard, J.E. / Marcus, J. / Klein, D.J. / Wang, X. / Pearson, M. ...Selnick, H.G. / Hess, J.F. / Tang, C. / Liu, K. / Schachter, J.B. / Ballard, J.E. / Marcus, J. / Klein, D.J. / Wang, X. / Pearson, M. / Savage, M.J. / Kaul, R. / Li, T.S. / Vocadlo, D.J. / Zhou, Y. / Zhu, Y. / Mu, C. / Wang, Y. / Wei, Z. / Bai, C. / Duffy, J.L. / McEachern, E.J.
External linksJ. Med. Chem. / PubMed:31487175
MethodsX-ray diffraction
Resolution2.86 Å
Structure data

PDB-6pm9:
Crystal structure of the core catalytic domain of human O-GlcNAcase bound to MK-8719
Method: X-RAY DIFFRACTION / Resolution: 2.86 Å

Chemicals

ChemComp-OQ1:
(3aR,5S,6S,7R,7aR)-5-(difluoromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / O-GLCNACASE / GH84 / INHIBITOR

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