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Title | Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin ResistantStaphylococcus aureus. |
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Journal, issue, pages | Acs Infect Dis., Vol. 5, Page 1896-1906, Year 2019 |
Publish date | Jun 10, 2019 (structure data deposition date) |
![]() | Reeve, S.M. / Si, D. / Krucinska, J. / Yan, Y. / Viswanathan, K. / Wang, S. / Holt, G.T. / Frenkel, M.S. / Ojewole, A.A. / Estrada, A. ...Reeve, S.M. / Si, D. / Krucinska, J. / Yan, Y. / Viswanathan, K. / Wang, S. / Holt, G.T. / Frenkel, M.S. / Ojewole, A.A. / Estrada, A. / Agabiti, S.S. / Alverson, J.B. / Gibson, N.D. / Priestley, N.D. / Wiemer, A.J. / Donald, B.R. / Wright, D.L. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.649 - 1.86 Å |
Structure data | ![]() PDB-6p9z: ![]() PDB-6pbo: |
Chemicals | ![]() ChemComp-MTX: ![]() ChemComp-NAP: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-O71: ![]() ChemComp-XNP: |
Source |
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![]() | antimicrobial protein / oxidoreductase / DHFR / methotrexate / antifolate / NADPH |