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-Structure paper
Title | Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as ROR gamma t inverse agonists. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 29, Page 2265-2269, Year 2019 |
Publish date | Jun 10, 2019 (structure data deposition date) |
![]() | Lu, Z. / Duan, J.J. / Xiao, H. / Neels, J. / Wu, D.R. / Weigelt, C.A. / Sack, J.S. / Khan, J. / Ruzanov, M. / An, Y. ...Lu, Z. / Duan, J.J. / Xiao, H. / Neels, J. / Wu, D.R. / Weigelt, C.A. / Sack, J.S. / Khan, J. / Ruzanov, M. / An, Y. / Yarde, M. / Karmakar, A. / Vishwakrishnan, S. / Baratam, V. / Shankarappa, H. / Vanteru, S. / Babu, V. / Basha, M. / Kumar Gupta, A. / Kumaravel, S. / Mathur, A. / Zhao, Q. / Salter-Cid, L.M. / Carter, P.H. / Murali Dhar, T.G. |
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Methods | X-ray diffraction |
Resolution | 2.8 Å |
Structure data | ![]() PDB-6p9f: |
Chemicals | ![]() ChemComp-O5A: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / RORGT / nuclear hormone receptor / ligand-binding domain / INVE agonist / TRANSFERASE-TRANSFERASE INHIBITOR complex |