EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
ジャーナル・号・ページ	J. Med. Chem., Vol. 63, Page 4655-4684, Year 2020
掲載日	2019年5月9日 (構造データの登録日)
著者	Priebbenow, D.L. / Leaver, D.J. / Nguyen, N. / Cleary, B. / Lagiakos, H.R. / Sanchez, J. / Xue, L. / Huang, F. / Sun, Y. / Mujumdar, P. ...Priebbenow, D.L. / Leaver, D.J. / Nguyen, N. / Cleary, B. / Lagiakos, H.R. / Sanchez, J. / Xue, L. / Huang, F. / Sun, Y. / Mujumdar, P. / Mudududdla, R. / Varghese, S. / Teguh, S. / Charman, S.A. / White, K.L. / Shackleford, D.M. / Katneni, K. / Cuellar, M. / Strasser, J.M. / Dahlin, J.L. / Walters, M.A. / Street, I.P. / Monahan, B.J. / Jarman, K.E. / Jousset Sabroux, H. / Falk, H. / Chung, M.C. / Hermans, S.J. / Downer, N.L. / Parker, M.W. / Voss, A.K. / Thomas, T. / Baell, J.B.
リンク	J. Med. Chem. / PubMed:32118427
手法	X線回折
解像度	1.75 - 2.8 Å
構造データ	PDB-6owh: Crystal structure of MYST acetyltransferase domain in complex with inhibitor 92 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-6owi: Crystal structure of MYST acetyltransferase domain in complex with inhibitor 85 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-6pd8: Crystal structure of MYST acetyltransferase domain in complex with inhibitor 39 手法: X-RAY DIFFRACTION / 解像度: 2.738 Å PDB-6pd9: Crystal structure of MYST acetyltransferase domain in complex with inhibitor 60 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-6pda: Crystal structure of MYST acetyltransferase domain in complex with inhibitor 74 手法: X-RAY DIFFRACTION / 解像度: 2.448 Å PDB-6pdb: Crystal structure of MYST acetyltransferase domain in complex with inhibitor 80 手法: X-RAY DIFFRACTION / 解像度: 2.42 Å PDB-6pdc: Crystal structure of MYST acetyltransferase domain in complex with inhibitor 42 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å PDB-6pdd: Crystal structure of MYST acetyltransferase domain in complex with inhibitor 41 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-6pde: Crystal structure of MYST acetyltransferase domain in complex with inhibitor 40 手法: X-RAY DIFFRACTION / 解像度: 2.22 Å PDB-6pdf: Crystal structure of MYST acetyltransferase domain in complex with inhibitor 55 手法: X-RAY DIFFRACTION / 解像度: 2.22 Å PDB-6pdg: Crystal structure of MYST acetyltransferase domain in complex with inhibitor 83 手法: X-RAY DIFFRACTION / 解像度: 1.919 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-NBJ: N'-[(2-fluorophenyl)sulfonyl]-3-iodobenzohydrazide ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM ChemComp-HOH: WATER ChemComp-NB7: N'-[(2-fluorophenyl)sulfonyl]benzohydrazide ChemComp-NA: Unknown entry / ナトリウムカチオン ChemComp-O9D: 5-ethoxy-2-fluoro-3-methyl-N'-(phenylsulfonyl)benzohydrazide ChemComp-O9G: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(1H-pyrazol-1-yl)benzohydrazide ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-O9J: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(pyridin-2-yl)benzohydrazide ChemComp-O9M: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(pyrimidin-2-yl)benzohydrazide ChemComp-O9P: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-[(prop-2-en-1-yl)oxy]benzohydrazide ChemComp-O9S: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-[(propan-2-yl)oxy]benzohydrazide ChemComp-O9V: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-propoxybenzohydrazide ChemComp-O9Y: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(2H-1,2,3-triazol-2-yl)benzohydrazide ChemComp-O9A*: 5-ethoxy-2-fluoro-3-methyl-N'-[(naphthalen-2-yl)sulfonyl]benzohydrazide
由来	homo sapiens (ヒト)
キーワード	TRANSFERASE/TRANSFERASE INHIBITOR / Inhibitor / Complex / MYST / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex / TRANSFERASE/TRANSERASE INHIBITOR / TRANSFERASE-TRANSERASE INHIBITOR complex