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-Structure paper
Title | High-Affinity Alkynyl Bisubstrate Inhibitors of NicotinamideN-Methyltransferase (NNMT). |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 9837-9873, Year 2019 |
Publish date | Apr 30, 2019 (structure data deposition date) |
![]() | Policarpo, R.L. / Decultot, L. / May, E. / Kuzmic, P. / Carlson, S. / Huang, D. / Chu, V. / Wright, B.A. / Dhakshinamoorthy, S. / Kannt, A. ...Policarpo, R.L. / Decultot, L. / May, E. / Kuzmic, P. / Carlson, S. / Huang, D. / Chu, V. / Wright, B.A. / Dhakshinamoorthy, S. / Kannt, A. / Rani, S. / Dittakavi, S. / Panarese, J.D. / Gaudet, R. / Shair, M.D. |
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Methods | X-ray diffraction |
Resolution | 2.25 Å |
Structure data | ![]() PDB-6orr: |
Chemicals | ![]() ChemComp-N37: ![]() ChemComp-GOL: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / methyltransferase nicotinamide / alkynyl bisubstrate inhibitor / alkyne linker methyltransferase inhibitor / high-affinity alkynyl nucleoside / SAM slow-binding inhibition / tight-binding inhibition / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex |