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-Structure paper
Title | AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies. |
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Journal, issue, pages | Cancer Discov, Vol. 8, Page 1582-1597, Year 2018 |
Publish date | Mar 6, 2019 (structure data deposition date) |
![]() | Caenepeel, S. / Brown, S.P. / Belmontes, B. / Moody, G. / Keegan, K.S. / Chui, D. / Whittington, D.A. / Huang, X. / Poppe, L. / Cheng, A.C. ...Caenepeel, S. / Brown, S.P. / Belmontes, B. / Moody, G. / Keegan, K.S. / Chui, D. / Whittington, D.A. / Huang, X. / Poppe, L. / Cheng, A.C. / Cardozo, M. / Houze, J. / Li, Y. / Lucas, B. / Paras, N.A. / Wang, X. / Taygerly, J.P. / Vimolratana, M. / Zancanella, M. / Zhu, L. / Cajulis, E. / Osgood, T. / Sun, J. / Damon, L. / Egan, R.K. / Greninger, P. / McClanaghan, J.D. / Gong, J. / Moujalled, D. / Pomilio, G. / Beltran, P. / Benes, C.H. / Roberts, A.W. / Huang, D.C. / Wei, A. / Canon, J. / Coxon, A. / Hughes, P.E. |
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Methods | X-ray diffraction / NMR (solution) |
Resolution | 1.48 - 2.4 Å |
Structure data | ![]() PDB-6o6f: ![]() PDB-6o6g: ![]() PDB-6oqb: ![]() PDB-6oqc: ![]() PDB-6oqd: ![]() PDB-6oqn: ![]() PDB-6ovc: |
Chemicals | ![]() ChemComp-LOD: ![]() ChemComp-HOH: ![]() ChemComp-LOJ: ![]() ChemComp-N0J: ![]() ChemComp-N0S: ![]() ChemComp-N0M: ![]() ChemComp-N0P: ![]() ChemComp-N8J: |
Source |
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![]() | APOPTOSIS/INHIBITOR / apoptosis / inhibition / APOPTOSIS-INHIBITOR complex / inhibitor / protein-protein interaction / Mcl1 / protein-protein / Mcl1 small molecule complex |