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Structure paper

TitleStructure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides.
Journal, issue, pagesAntimicrob. Agents Chemother., Vol. 63, Year 2019
Publish dateMar 28, 2019 (structure data deposition date)
AuthorsKhabibullina, N.F. / Tereshchenkov, A.G. / Komarova, E.S. / Syroegin, E.A. / Shiriaev, D.I. / Paleskava, A. / Kartsev, V.G. / Bogdanov, A.A. / Konevega, A.L. / Dontsova, O.A. ...Khabibullina, N.F. / Tereshchenkov, A.G. / Komarova, E.S. / Syroegin, E.A. / Shiriaev, D.I. / Paleskava, A. / Kartsev, V.G. / Bogdanov, A.A. / Konevega, A.L. / Dontsova, O.A. / Sergiev, P.V. / Osterman, I.A. / Polikanov, Y.S.
External linksAntimicrob. Agents Chemother. / PubMed:30936109
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-6of1:
Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-DI0:
Dirithromycin / antibiotic*YM

ChemComp-K:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
  • thermus thermophilus hb8 (bacteria)
  • thermus thermophilus (strain hb8 / atcc 27634 / dsm 579) (bacteria)
  • enterobacteria phage t4 (virus)
KeywordsRIBOSOME / Dirithromycin / macrolide / antibiotic / 70S ribosome / inhibitor / nascent peptide exit tunnel / ribosomal protein uL4

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