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TitleDesign, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 141, Page 5051-5061, Year 2019
Publish dateMar 13, 2019 (structure data deposition date)
AuthorsMatsushita, T. / Sati, G.C. / Kondasinghe, N. / Pirrone, M.G. / Kato, T. / Waduge, P. / Kumar, H.S. / Sanchon, A.C. / Dobosz-Bartoszek, M. / Shcherbakov, D. ...Matsushita, T. / Sati, G.C. / Kondasinghe, N. / Pirrone, M.G. / Kato, T. / Waduge, P. / Kumar, H.S. / Sanchon, A.C. / Dobosz-Bartoszek, M. / Shcherbakov, D. / Juhas, M. / Hobbie, S.N. / Schrepfer, T. / Chow, C.S. / Polikanov, Y.S. / Schacht, J. / Vasella, A. / Bottger, E.C. / Crich, D.
External linksJ. Am. Chem. Soc. / PubMed:30793894
MethodsX-ray diffraction
Resolution2.75 Å
Structure data

PDB-6o97:
Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-LUJ:
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxyc

ChemComp-K:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
  • thermus thermophilus hb8 (bacteria)
  • thermus thermophilus (strain hb8 / atcc 27634 / dsm 579) (bacteria)
  • enterobacteria phage t4 (virus)
KeywordsRIBOSOME/ANTIBIOTIC / Propylamycin / aminoglycosides / antibiotic / 70S ribosome / inhibition of translation / decoding center / RIBOSOME-ANTIBIOTIC complex

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