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-Structure paper
Title | Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 6223-6240, Year 2019 |
Publish date | Mar 12, 2019 (structure data deposition date) |
Authors | Bryan, M.C. / Drobnick, J. / Gobbi, A. / Kolesnikov, A. / Chen, Y. / Rajapaksa, N. / Ndubaku, C. / Feng, J. / Chang, W. / Francis, R. ...Bryan, M.C. / Drobnick, J. / Gobbi, A. / Kolesnikov, A. / Chen, Y. / Rajapaksa, N. / Ndubaku, C. / Feng, J. / Chang, W. / Francis, R. / Yu, C. / Choo, E.F. / DeMent, K. / Ran, Y. / An, L. / Emson, C. / Huang, Z. / Sujatha-Bhaskar, S. / Brightbill, H. / DiPasquale, A. / Maher, J. / Wai, J. / McKenzie, B.S. / Lupardus, P.J. / Zarrin, A.A. / Kiefer, J.R. |
External links | J. Med. Chem. / PubMed:31082230 |
Methods | X-ray diffraction |
Resolution | 1.77 - 2.51 Å |
Structure data | PDB-6o8u: PDB-6o94: PDB-6o95: PDB-6o9d: |
Chemicals | ChemComp-LS7: ChemComp-SO4: ChemComp-GOL: ChemComp-HOH: ChemComp-CA: ChemComp-LRS: ChemComp-LSV: ChemComp-LTY: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / kinase / inhibitor / inflammation / lupus / TRANSFERASE-TRANSFERASE INHIBITOR complex / IMMUNE SYSTEM / IRAK4 / IRAK1 / IRAK2 / IRAK3 |