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-Structure paper
Title | Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. |
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Journal, issue, pages | J. Biol. Chem., Vol. 294, Page 10607-10618, Year 2019 |
Publish date | Mar 4, 2019 (structure data deposition date) |
![]() | Gerlits, O. / Kong, X. / Cheng, X. / Wymore, T. / Blumenthal, D.K. / Taylor, P. / Radic, Z. / Kovalevsky, A. |
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Methods | X-ray diffraction |
Resolution | 2.152 - 2.801 Å |
Structure data | ![]() PDB-6o5r: ![]() PDB-6o5s: ![]() PDB-6o5v: ![]() PDB-6o66: |
Chemicals | ![]() ChemComp-LND: ![]() ChemComp-CL: ![]() ChemComp-HOH: ![]() ChemComp-VX: ![]() ChemComp-NO3: ![]() ChemComp-GOL: |
Source |
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![]() | HYDROLASE / oxime reactivator / imidazole-based oxime / RS-170B / VX-phosphonylated / VX-hAChE / human acetylcholinesterase |