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-Structure paper
Title | Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 6575-6596, Year 2019 |
Publish date | Feb 25, 2019 (structure data deposition date) |
![]() | Lin, J. / Lu, W. / Caravella, J.A. / Campbell, A.M. / Diebold, R.B. / Ericsson, A. / Fritzen, E. / Gustafson, G.R. / Lancia Jr., D.R. / Shelekhin, T. ...Lin, J. / Lu, W. / Caravella, J.A. / Campbell, A.M. / Diebold, R.B. / Ericsson, A. / Fritzen, E. / Gustafson, G.R. / Lancia Jr., D.R. / Shelekhin, T. / Wang, Z. / Castro, J. / Clarke, A. / Gotur, D. / Josephine, H.R. / Katz, M. / Diep, H. / Kershaw, M. / Yao, L. / Kauffman, G. / Hubbs, S.E. / Luke, G.P. / Toms, A.V. / Wang, L. / Bair, K.W. / Barr, K.J. / Dinsmore, C. / Walker, D. / Ashwell, S. |
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Methods | X-ray diffraction |
Resolution | 2.5 - 2.8 Å |
Structure data | ![]() PDB-6o2y: ![]() PDB-6o2z: |
Chemicals | ![]() ChemComp-LJY: ![]() ChemComp-NAP: ![]() ChemComp-BME: ![]() ChemComp-HOH: ![]() ChemComp-LJV: ![]() ChemComp-GOL: |
Source |
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![]() | Oxidoreductase/Inhibitor / IDH1 / allosteric inhibitor / Oxidoreductase / Inhibitor complex / Oxidoreductase-Inhibitor complex |