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-Structure paper
Title | Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses. |
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Journal, issue, pages | Sci Adv, Vol. 5, Page eaax9586-eaax9586, Year 2019 |
Publish date | Dec 21, 2018 (structure data deposition date) |
Authors | Blumberg, L.J. / Humphries, J.E. / Jones, S.D. / Pearce, L.B. / Holgate, R. / Hearn, A. / Cheung, J. / Mahmood, A. / Del Tito, B. / Graydon, J.S. ...Blumberg, L.J. / Humphries, J.E. / Jones, S.D. / Pearce, L.B. / Holgate, R. / Hearn, A. / Cheung, J. / Mahmood, A. / Del Tito, B. / Graydon, J.S. / Stolz, L.E. / Bitonti, A. / Purohit, S. / de Graaf, D. / Kacena, K. / Andersen, J.T. / Christianson, G.J. / Roopenian, D.C. / Hubbard, J.J. / Gandhi, A.K. / Lasseter, K. / Pyzik, M. / Blumberg, R.S. |
External links | Sci Adv / PubMed:31897428 |
Methods | X-ray diffraction |
Resolution | 2.381 Å |
Structure data | PDB-6nha: |
Chemicals | ChemComp-NHE: ChemComp-HOH: |
Source |
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Keywords | IMMUNE SYSTEM / FcRn / B2M / Circulating IgG and IgG immune complex / SYNT001 |