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-Structure paper
Title | Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation. |
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Journal, issue, pages | J. Biol. Chem., Vol. 294, Page 9029-9036, Year 2019 |
Publish date | Dec 21, 2018 (structure data deposition date) |
![]() | Johnson, E. / McTigue, M. / Gallego, R.A. / Johnson, T.W. / Timofeevski, S. / Maestre, M. / Fisher, T.S. / Kania, R. / Sawasdikosol, S. / Burakoff, S. / Cronin, C.N. |
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Methods | X-ray diffraction |
Resolution | 2.05 - 2.966 Å |
Structure data | ![]() PDB-6nfy: ![]() PDB-6nfz: ![]() PDB-6ng0: |
Chemicals | ![]() ChemComp-B49: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / Kinase / 3D domain swap / active state / SIGNALING PROTEIN / dimer / inactive state |