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-Structure paper
Title | Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 3971-3988, Year 2019 |
Publish date | Dec 17, 2018 (structure data deposition date) |
![]() | Lee, T. / Christov, P.P. / Shaw, S. / Tarr, J.C. / Zhao, B. / Veerasamy, N. / Jeon, K.O. / Mills, J.J. / Bian, Z. / Sensintaffar, J.L. ...Lee, T. / Christov, P.P. / Shaw, S. / Tarr, J.C. / Zhao, B. / Veerasamy, N. / Jeon, K.O. / Mills, J.J. / Bian, Z. / Sensintaffar, J.L. / Arnold, A.L. / Fogarty, S.A. / Perry, E. / Ramsey, H.E. / Cook, R.S. / Hollingshead, M. / Davis Millin, M. / Lee, K.M. / Koss, B. / Budhraja, A. / Opferman, J.T. / Kim, K. / Arteaga, C.L. / Moore, W.J. / Olejniczak, E.T. / Savona, M.R. / Fesik, S.W. |
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Methods | X-ray diffraction |
Resolution | 1.85 Å |
Structure data | ![]() PDB-6ne5: |
Chemicals | ![]() ChemComp-KJP: ![]() ChemComp-HOH: |
Source |
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![]() | APOPTOSIS / structure based drug discovery; apoptosis; cancer; Mcl-1; drug discovery |