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-Structure paper
Title | Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates. |
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Journal, issue, pages | Drug Metab. Dispos., Vol. 47, Page 995-1003, Year 2019 |
Publish date | Dec 13, 2018 (structure data deposition date) |
Authors | Lombardo, M.N. / G-Dayanandan, N. / Keshipeddy, S. / Zhou, W. / Si, D. / Reeve, S.M. / Alverson, J. / Barney, P. / Walker, L. / Hoody, J. ...Lombardo, M.N. / G-Dayanandan, N. / Keshipeddy, S. / Zhou, W. / Si, D. / Reeve, S.M. / Alverson, J. / Barney, P. / Walker, L. / Hoody, J. / Priestley, N.D. / Obach, R.S. / Wright, D.L. |
External links | Drug Metab. Dispos. / PubMed:31201212 |
Methods | X-ray diffraction |
Resolution | 2.243 Å |
Structure data | PDB-6nd2: |
Chemicals | ChemComp-GOL: ChemComp-G8J: ChemComp-XNP: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE / DHFR / Propargyl-linked antifolates / antibiotics / antifolates |