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Structure paper

TitleStructural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase eta.
Journal, issue, pagesBiochem. J., Vol. 476, Page 747-758, Year 2019
Publish dateOct 31, 2018 (structure data deposition date)
AuthorsOuzon-Shubeita, H. / Baker, M. / Koag, M.C. / Lee, S.
External linksBiochem. J. / PubMed:30709915
MethodsX-ray diffraction
Resolution2.04 Å
Structure data

PDB-6mxo:
Structure of HPoleta incorporating dCTP opposite the 3-prime Pt(DACH)-GG
Method: X-RAY DIFFRACTION / Resolution: 2.04 Å

Chemicals

ChemComp-0KX:
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-9RD:
(cyclohex-1-ene-1,2-diamine)platinum(2+)

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsNUCLEAR PROTEIN/DNA / Y-family DNA polymerase / Pt(DACH)-GG / TRANSFERASE-DNA-INHIBITOR complex / NUCLEAR PROTEIN / NUCLEAR PROTEIN-DNA complex

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