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-Structure paper
Title | Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 10, Page 92-97, Year 2019 |
Publish date | Oct 30, 2018 (structure data deposition date) |
Authors | Siu, T. / Altman, M.D. / Baltus, G.A. / Childers, M. / Ellis, J.M. / Gunaydin, H. / Hatch, H. / Ho, T. / Jewell, J. / Lacey, B.M. ...Siu, T. / Altman, M.D. / Baltus, G.A. / Childers, M. / Ellis, J.M. / Gunaydin, H. / Hatch, H. / Ho, T. / Jewell, J. / Lacey, B.M. / Lesburg, C.A. / Pan, B.S. / Sauvagnat, B. / Schroeder, G.K. / Xu, S. |
External links | ACS Med Chem Lett / PubMed:30655953 |
Methods | X-ray diffraction |
Resolution | 1.362 - 2.47 Å |
Structure data | PDB-6mx0: PDB-6mx3: PDB-6mxe: |
Chemicals | ChemComp-CA: ChemComp-HOH: ChemComp-K5P: ChemComp-K5S: |
Source |
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Keywords | IMMUNE SYSTEM / INNATE IMMUNITY / SIGNALING / OPEN CONFORMATION / immune system/inhibitor / immune system-inhibitor complex |