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-Structure paper
| Title | Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 59, Page 4948-4964, Year 2016 |
| Publish date | Oct 30, 2018 (structure data deposition date) |
 Authors | Huang, W.S. / Liu, S. / Zou, D. / Thomas, M. / Wang, Y. / Zhou, T. / Romero, J. / Kohlmann, A. / Li, F. / Qi, J. ...Huang, W.S. / Liu, S. / Zou, D. / Thomas, M. / Wang, Y. / Zhou, T. / Romero, J. / Kohlmann, A. / Li, F. / Qi, J. / Cai, L. / Dwight, T.A. / Xu, Y. / Xu, R. / Dodd, R. / Toms, A. / Parillon, L. / Lu, X. / Anjum, R. / Zhang, S. / Wang, F. / Keats, J. / Wardwell, S.D. / Ning, Y. / Xu, Q. / Moran, L.E. / Mohemmad, Q.K. / Jang, H.G. / Clackson, T. / Narasimhan, N.I. / Rivera, V.M. / Zhu, X. / Dalgarno, D. / Shakespeare, W.C. |
 External links | J. Med. Chem. / PubMed:27144831 |
| Methods | X-ray diffraction |
| Resolution | 1.96 Å |
| Structure data |  PDB-6mx8: |
| Chemicals |  ChemComp-6GY:  ChemComp-HOH: |
| Source |
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 Keywords | TRANSFERASE / Alk Kinase / Brigatinib / Tyrosine Kinase |
homo sapiens (human)