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TitleThe Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2
Journal, issue, pagesMol. Cancer Ther., Vol. 16, Page 2486-2501, Year 2017
Publish dateOct 29, 2018 (structure data deposition date)
AuthorsHarney, A.S. / Karagiannis, G.S. / Pignatelli, J. / Smith, B.D. / Kadioglu, E. / Wise, S.C. / Hood, M.M. / Kaufman, M.D. / Leary, C.B. / Lu, W.P. ...Harney, A.S. / Karagiannis, G.S. / Pignatelli, J. / Smith, B.D. / Kadioglu, E. / Wise, S.C. / Hood, M.M. / Kaufman, M.D. / Leary, C.B. / Lu, W.P. / Al-Ani, G. / Chen, X. / Entenberg, D. / Oktay, M.H. / Wang, Y. / Chun, L. / De Palma, M. / Jones, J.G. / Flynn, D.L. / Condeelis, J.S.
External linksMol. Cancer Ther. / PubMed:28838996
MethodsX-ray diffraction
Resolution2.05 Å
Structure data

PDB-6mwe:
CRYSTAL STRUCTURE OF TIE2 IN COMPLEX WITH DECIPERA COMPOUND DP1919
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-919:
4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / TIE2 / DP1919 / EMERALDBIO / DECIPHERA

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