+Search query
-Structure paper
Title | Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor. |
---|---|
Journal, issue, pages | Bioorg. Med. Chem., Vol. 27, Page 457-469, Year 2019 |
Publish date | Oct 4, 2018 (structure data deposition date) |
Authors | Sperandio, D. / Aktoudianakis, V. / Babaoglu, K. / Chen, X. / Elbel, K. / Chin, G. / Corkey, B. / Du, J. / Jiang, B. / Kobayashi, T. ...Sperandio, D. / Aktoudianakis, V. / Babaoglu, K. / Chen, X. / Elbel, K. / Chin, G. / Corkey, B. / Du, J. / Jiang, B. / Kobayashi, T. / Mackman, R. / Martinez, R. / Yang, H. / Zablocki, J. / Kusam, S. / Jordan, K. / Webb, H. / Bates, J.G. / Lad, L. / Mish, M. / Niedziela-Majka, A. / Metobo, S. / Sapre, A. / Hung, M. / Jin, D. / Fung, W. / Kan, E. / Eisenberg, G. / Larson, N. / Newby, Z.E.R. / Lansdon, E. / Tay, C. / Neve, R.M. / Shevick, S.L. / Breckenridge, D.G. |
External links | Bioorg. Med. Chem. / PubMed:30606676 |
Methods | X-ray diffraction |
Resolution | 1.271 - 1.85 Å |
Structure data | PDB-6mo7: PDB-6mo8: PDB-6mo9: PDB-6moa: |
Chemicals | ChemComp-JWA: ChemComp-HOH: ChemComp-JWD: ChemComp-SO4: ChemComp-JVY: ChemComp-JW4: ChemComp-GOL: |
Source |
|
Keywords | transcription/transcription inhibitor / Inhibitor / epigenetic reader / bromodomain / transcription-transcription inhibitor complex / Bromo domain |