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Structure paper

TitleCa2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.
Journal, issue, pagesNat Commun, Vol. 10, Page 1514-1514, Year 2019
Publish dateAug 29, 2018 (structure data deposition date)
AuthorsYoder, J.B. / Ben-Johny, M. / Farinelli, F. / Srinivasan, L. / Shoemaker, S.R. / Tomaselli, G.F. / Gabelli, S.B. / Amzel, L.M.
External linksNat Commun / PubMed:30944319
MethodsX-ray diffraction
Resolution1.799 - 3.3 Å
Structure data

PDB-6mba:
Crystal Structure of Human Nav1.4 CTerminal Domain in Complex with apo Calmodulin
Method: X-RAY DIFFRACTION / Resolution: 1.799 Å

PDB-6mc9:
Crystal Structure of Human Nav1.4 C-Terminal (1599-1754) domain in complex with calcium-bound calmodulin
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CO3:
CARBONATE ION

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
  • rattus norvegicus (Norway rat)
KeywordsCALMODULIN-BINDING PROTEIN / SCN4A / voltage gated sodium channel / calmodulin / MEMBRANE PROTEIN / PROTEIN BINDING

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