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TitleNovel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Journal, issue, pagesProtein Cell, Vol. 11, Page 723-739, Year 2020
Publish dateFeb 27, 2020 (structure data deposition date)
AuthorsXiong, R. / Zhang, L. / Li, S. / Sun, Y. / Ding, M. / Wang, Y. / Zhao, Y. / Wu, Y. / Shang, W. / Jiang, X. ...Xiong, R. / Zhang, L. / Li, S. / Sun, Y. / Ding, M. / Wang, Y. / Zhao, Y. / Wu, Y. / Shang, W. / Jiang, X. / Shan, J. / Shen, Z. / Tong, Y. / Xu, L. / Chen, Y. / Liu, Y. / Zou, G. / Lavillete, D. / Zhao, Z. / Wang, R. / Zhu, L. / Xiao, G. / Lan, K. / Li, H. / Xu, K.
External linksProtein Cell / PubMed:32754890
MethodsX-ray diffraction
Resolution1.76 Å
Structure data

PDB-6m2b:
Crystal structure of human dihydroorotate dehydrogenase (DHODH) with S416
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

Chemicals

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

ChemComp-ORO:
OROTIC ACID

ChemComp-EZO:
2-[(E)-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-methyl-hydrazinylidene]methyl]benzoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / inhibitor / complex / BIOSYNTHETIC PROTEIN

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