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Structure paper

TitleA novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity.
Journal, issue, pagesCancer Lett., Vol. 495, Page 22-32, Year 2020
Publish dateJan 17, 2020 (structure data deposition date)
AuthorsDu, T. / Lin, S. / Ji, M. / Xue, N. / Liu, Y. / Zhang, Z. / Zhang, K. / Zhang, J. / Zhang, Y. / Wang, Q. ...Du, T. / Lin, S. / Ji, M. / Xue, N. / Liu, Y. / Zhang, Z. / Zhang, K. / Zhang, J. / Zhang, Y. / Wang, Q. / Sheng, L. / Li, Y. / Lu, D. / Chen, X. / Xu, H.
External linksCancer Lett. / PubMed:32931884
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-6ls4:
A novel anti-tumor agent S-40 in complex with tubulin
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-GOL:
GLYCEROL

ChemComp-S40:
3-[(4-cyclopropylphenyl)sulfonylamino]-4-methyl-N-(pyridin-3-ylmethyl)benzamide

ChemComp-HOH:
WATER

Source
  • sus scrofa (pig)
KeywordsSTRUCTURAL PROTEIN / mitosis / ANTITUMOR PROTEIN

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