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Structure paper

TitleMolecular recognition of a single-chain Fv antibody specific for GA-pyridine, an advanced glycation end-product (AGE), elucidated using biophysical techniques and synthetic antigen analogues.
Journal, issue, pagesJ. Biochem., Vol. 170, Page 379-387, Year 2021
Publish dateNov 19, 2019 (structure data deposition date)
AuthorsKobashigawa, Y. / Ohara, T. / Morita, K. / Toyota, Y. / Nakamura, T. / Kotani, S. / Arimori, T. / Yamauchi, S. / Liu, C. / Kitazaki, M. ...Kobashigawa, Y. / Ohara, T. / Morita, K. / Toyota, Y. / Nakamura, T. / Kotani, S. / Arimori, T. / Yamauchi, S. / Liu, C. / Kitazaki, M. / Wakeyama-Miyazaki, Y. / Suwa, Y. / Uchida-Kamekura, M. / Fukuda, N. / Sato, T. / Nakajima, M. / Takagi, J. / Yamagata, Y. / Morioka, H.
External linksJ. Biochem. / PubMed:34185078
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-6lcs:
Crystal structure of 73MuL9 Fv-clasp fragment in complex with GA-pyridine analogue
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-E9R:
(2~{S})-6-[4-(hydroxymethyl)-3-oxidanyl-pyridin-1-ium-1-yl]-2-(phenylmethoxycarbonylamino)hexanoic acid

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / AGE / antibody fragment / fv-clasp

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