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Structure paper

TitleCrystal structures of the RNA triphosphatase fromTrypanosoma cruziprovide insights into how it recognizes the 5'-end of the RNA substrate.
Journal, issue, pagesJ. Biol. Chem., Vol. 295, Page 9076-9086, Year 2020
Publish dateNov 3, 2019 (structure data deposition date)
AuthorsTakagi, Y. / Kuwabara, N. / Dang, T.T. / Furukawa, K. / Ho, C.K.
External linksJ. Biol. Chem. / PubMed:32381506
MethodsX-ray diffraction
Resolution2.2 - 2.6 Å
Structure data

PDB-6l7v:
Crystal structure of Cet1 from Trypanosoma cruzi in complex with tripolyphosphate, manganese and iodide ions.
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-6l7w:
Crystal structure of Cet1 from Trypanosoma cruzi in complex with manganese ion.
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-6l7x:
Crystal structure of Cet1 from Trypanosoma cruzi in complex with #951 ligand
Method: X-RAY DIFFRACTION / Resolution: 2.39 Å

PDB-6l7y:
Crystal structure of Cet1 from Trypanosoma cruzi in complex with #466 ligand.
Method: X-RAY DIFFRACTION / Resolution: 2.51 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-3PO:
TRIPHOSPHATE

ChemComp-IOD:
IODIDE ION

ChemComp-HOH:
WATER

ChemComp-E7R:
1,3-dimethyl-7-propyl-purine-2,6-dione

ChemComp-SO4:
SULFATE ION

ChemComp-JJY:
3,4,6,7-tetrahydroacridine-1,8(2H,5H)-dione

Source
  • trypanosoma cruzi strain cl brener (eukaryote)
KeywordsHYDROLASE / mRNA capping / RNA triphosphatase

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