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Structure paper

TitleRevealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance.
Journal, issue, pagesIscience, Vol. 20, Page 489-496, Year 2019
Publish dateJul 24, 2019 (structure data deposition date)
AuthorsYao, B. / Wei, Y. / Zhang, S. / Tian, S. / Xu, S. / Wang, R. / Zheng, W. / Li, Y.
External linksIscience / PubMed:31655060
MethodsX-ray diffraction
Resolution1.7 - 2.8 Å
Structure data

PDB-6kkb:
A novel agonist of THRb
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-6kke:
THRb mutation with a novel agonist
Method: X-RAY DIFFRACTION / Resolution: 2.577 Å

PDB-6knu:
THRb mutation with a novel agonist
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6knv:
THRb mutation with a novel agonist
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-6knw:
THRb mutation with a novel agonist
Method: X-RAY DIFFRACTION / Resolution: 2.67 Å

Chemicals

ChemComp-8HO:
2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid / medication, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / agonist / thyroid hormone receptor / anemia

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