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TitleSmall molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model
Journal, issue, pagesNat Commun, Vol. 12, Year 2021
Publish dateDec 20, 2018 (structure data deposition date)
AuthorsShibata, T. / Nagano, K. / Ueyama, M. / Ninomiya, K. / Hirose, T. / Nagai, Y. / Ishikawa, K. / Kawai, G. / Nakatani, K.
External linksNat Commun / Search PubMed
MethodsNMR (solution)
Structure data

PDB-6izp:
Solution structure of the complex of naphthyridine carbamate dimer and an RNA with UGGAA-UGGAA pentad
Method: SOLUTION NMR

Chemicals

ChemComp-B2R:
3-[3-[(7-methyl-1,8-naphthyridin-2-yl)carbamoyloxy]propylamino]propyl ~{N}-(7-methyl-1,8-naphthyridin-2-yl)carbamate

Source
  • homo sapiens (human)
KeywordsRNA / SCA31 / UGGAA repeat / small molecule / drug

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