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TitleTricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists.
Journal, issue, pagesJ. Med. Chem., Vol. 62, Page 1593-1608, Year 2019
Publish dateNov 27, 2018 (structure data deposition date)
AuthorsScott, J.S. / Bailey, A. / Buttar, D. / Carbajo, R.J. / Curwen, J. / Davey, P.R.J. / Davies, R.D.M. / Degorce, S.L. / Donald, C. / Gangl, E. ...Scott, J.S. / Bailey, A. / Buttar, D. / Carbajo, R.J. / Curwen, J. / Davey, P.R.J. / Davies, R.D.M. / Degorce, S.L. / Donald, C. / Gangl, E. / Greenwood, R. / Groombridge, S.D. / Johnson, T. / Lamont, S. / Lawson, M. / Lister, A. / Morrow, C.J. / Moss, T.A. / Pink, J.H. / Polanski, R.
External linksJ. Med. Chem. / PubMed:30640465
MethodsX-ray diffraction
Resolution1.84 Å
Structure data

PDB-6iar:
Tricyclic indazoles a novel class of selective estrogen receptor degrader antagonists
Method: X-RAY DIFFRACTION / Resolution: 1.84 Å

Chemicals

ChemComp-H8W:
3-[4-[(6~{R})-7-(2-methylpropyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]phenyl]propanoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / Nuclear Hormone Receptor Inhibitor Downregulation Estrogen receptor modulators

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