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Title | Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel. |
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Journal, issue, pages | ACS Med Chem Lett, Vol. 9, Page 1039-1044, Year 2018 |
Publish date | Sep 13, 2018 (structure data deposition date) |
Authors | Haile, P.A. / Casillas, L.N. / Bury, M.J. / Mehlmann, J.F. / Singhaus Jr., R. / Charnley, A.K. / Hughes, T.V. / DeMartino, M.P. / Wang, G.Z. / Romano, J.J. ...Haile, P.A. / Casillas, L.N. / Bury, M.J. / Mehlmann, J.F. / Singhaus Jr., R. / Charnley, A.K. / Hughes, T.V. / DeMartino, M.P. / Wang, G.Z. / Romano, J.J. / Dong, X. / Plotnikov, N.V. / Lakdawala, A.S. / Convery, M.A. / Votta, B.J. / Lipshutz, D.B. / Desai, B.M. / Swift, B. / Capriotti, C.A. / Berger, S.B. / Mahajan, M.K. / Reilly, M.A. / Rivera, E.J. / Sun, H.H. / Nagilla, R. / LePage, C. / Ouellette, M.T. / Totoritis, R.D. / Donovan, B.T. / Brown, B.S. / Chaudhary, K.W. / Gough, P.J. / Bertin, J. / Marquis, R.W. |
External links | ACS Med Chem Lett / PubMed:30344914 |
Methods | X-ray diffraction |
Resolution | 2.53 Å |
Structure data | PDB-6hmx: |
Chemicals | ChemComp-GEZ: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / Kinase / kinase inhibitor / Complex / Structure based drug discovery |