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Structure paper

TitleStructural basis of a small molecule targeting RNA for a specific splicing correction.
Journal, issue, pagesNat. Chem. Biol., Vol. 15, Page 1191-1198, Year 2019
Publish dateSep 12, 2018 (structure data deposition date)
AuthorsCampagne, S. / Boigner, S. / Rudisser, S. / Moursy, A. / Gillioz, L. / Knorlein, A. / Hall, J. / Ratni, H. / Clery, A. / Allain, F.H.
External linksNat. Chem. Biol. / PubMed:31636429
MethodsNMR (solution)
Structure data

PDB-6hmi:
Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7
Method: SOLUTION NMR

PDB-6hmo:
Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7 in complex with the SMN-C5 splicing modifier
Method: SOLUTION NMR

Chemicals

ChemComp-GDZ:
2-(8-fluoranyl-2-methyl-imidazo[1,2-a]pyridin-6-yl)-7-(4-methylpiperazin-1-yl)pyrido[1,2-a]pyrimidin-4-one

Source
  • homo sapiens (human)
KeywordsRNA / weak 5'-splice site / U1 snRNA / Spinal Muscular Atrophy / bulge nucleotide / 5'-splice site bulge repair / splicing modifier

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