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Structure paper

TitleAllosteric Inhibition as a New Mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated Form of Coagulation Factor XI.
Journal, issue, pagesJ. Mol. Biol., Vol. 431, Page 4817-4833, Year 2019
Publish dateAug 27, 2018 (structure data deposition date)
AuthorsSchaefer, M. / Buchmueller, A. / Dittmer, F. / Strassburger, J. / Wilmen, A.
External linksJ. Mol. Biol. / PubMed:31655039
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-6hhc:
Allosteric Inhibition as a new mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated form of Coagulation Factor XI
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

Source
  • homo sapiens (human)
KeywordsBLOOD CLOTTING / FXIA ANTIBODY FAB / BLOOD CLOTTING-IMMUNE COMPLEX

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