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-Structure paper
Title | Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. U.S.A., Year 2019 |
Publish date | Nov 4, 2015 (structure data deposition date) |
![]() | Baragana, B. / Forte, B. / Choi, R. / Nakazawa Hewitt, S. / Bueren-Calabuig, J.A. / Pisco, J.P. / Peet, C. / Dranow, D.M. / Robinson, D.A. / Jansen, C. ...Baragana, B. / Forte, B. / Choi, R. / Nakazawa Hewitt, S. / Bueren-Calabuig, J.A. / Pisco, J.P. / Peet, C. / Dranow, D.M. / Robinson, D.A. / Jansen, C. / Norcross, N.R. / Vinayak, S. / Anderson, M. / Brooks, C.F. / Cooper, C.A. / Damerow, S. / Delves, M. / Dowers, K. / Duffy, J. / Edwards, T.E. / Hallyburton, I. / Horst, B.G. / Hulverson, M.A. / Ferguson, L. / Jimenez-Diaz, M.B. / Jumani, R.S. / Lorimer, D.D. / Love, M.S. / Maher, S. / Matthews, H. / McNamara, C.W. / Miller, P. / O'Neill, S. / Ojo, K.K. / Osuna-Cabello, M. / Pinto, E. / Post, J. / Riley, J. / Rottmann, M. / Sanz, L.M. / Scullion, P. / Sharma, A. / Shepherd, S.M. / Shishikura, Y. / Simeons, F.R.C. / Stebbins, E.E. / Stojanovski, L. / Straschil, U. / Tamaki, F.K. / Tamjar, J. / Torrie, L.S. / Vantaux, A. / Witkowski, B. / Wittlin, S. / Yogavel, M. / Zuccotto, F. / Angulo-Barturen, I. / Sinden, R. / Baum, J. / Gamo, F.J. / Maser, P. / Kyle, D.E. / Winzeler, E.A. / Myler, P.J. / Wyatt, P.G. / Floyd, D. / Matthews, D. / Striepen, B. / Huston, C.D. / Gray, D.W. / Fairlamb, A.H. / Pisliakov, A.V. / Walpole, C. / Read, K.D. / Van Voorhis, W.C. / Gilbert, I.H. |
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Methods | X-ray diffraction |
Resolution | 1.46 - 2.2 Å |
Structure data | ![]() PDB-5eln: ![]() PDB-5elo: ![]() PDB-6agt: ![]() PDB-6hcu: ![]() PDB-6hcv: ![]() PDB-6hcw: |
Chemicals | ![]() ChemComp-LYS: ![]() ChemComp-EDO: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-KRS: ![]() ChemComp-SO4: ![]() ChemComp-9X0: ![]() ChemComp-CO: ![]() ChemComp-FMT: ![]() ChemComp-MLA: ![]() ChemComp-FYB: ![]() ChemComp-PEG: ![]() ChemComp-HIS: ![]() ChemComp-TRS: ![]() ChemComp-FYE: |
Source |
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![]() | LIGASE / SSGCID / Lysine--tRNA ligase / Cryptosporidium parvum / ATP binding / aminoacylation / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease / ligase/ligase inhibitor / cladosporin / ligase-ligase inhibitor complex / LIGASE/INHIBITOR / KRS / CHROMONE INHIBITOR / ATP BINDING PROTEIN / LIGASE-INHIBITOR COMPLEX / TRANSFERASE / ADENYLYLTRANSFERASE ACTIVITY / TRNA BINDING |