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-Structure paper
Title | Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 10299-10309, Year 2018 |
Publish date | Mar 30, 2018 (structure data deposition date) |
Authors | Bhatia, S. / Krieger, V. / Groll, M. / Osko, J.D. / Reßing, N. / Ahlert, H. / Borkhardt, A. / Kurz, T. / Christianson, D.W. / Hauer, J. / Hansen, F.K. |
External links | J. Med. Chem. / PubMed:30365892 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2.5 Å |
Structure data | PDB-6cw8: PDB-6h39: |
Chemicals | ChemComp-ZN: ChemComp-K: ChemComp-FGY: ChemComp-EDO: ChemComp-HOH: ChemComp-MG: ChemComp-CL: ChemComp-MES: ChemComp-SO4: |
Source |
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Keywords | HYDROLASE / Histone deacetylase / metallohydrolase / HYDROLASE-HYDROLASE INHIBITOR complex / Proteasome / Histone-Deacetylase / Dual Binding Inhibitor / Binding Analysis |