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Title | A Triazolotriazine-Based Dual GSK-3 beta /CK-1 delta Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition. |
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Journal, issue, pages | Chemmedchem, Vol. 14, Page 310-314, Year 2019 |
Publish date | Jul 10, 2018 (structure data deposition date) |
Authors | Redenti, S. / Marcovich, I. / De Vita, T. / Perez, C. / De Zorzi, R. / Demitri, N. / Perez, D.I. / Bottegoni, G. / Bisignano, P. / Bissaro, M. ...Redenti, S. / Marcovich, I. / De Vita, T. / Perez, C. / De Zorzi, R. / Demitri, N. / Perez, D.I. / Bottegoni, G. / Bisignano, P. / Bissaro, M. / Moro, S. / Martinez, A. / Storici, P. / Spalluto, G. / Cavalli, A. / Federico, S. |
External links | Chemmedchem / PubMed:30548443 |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | PDB-6h0u: |
Chemicals | ChemComp-FKB: ChemComp-MLI: ChemComp-GOL: ChemComp-CL: ChemComp-NA: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / Protein Kinase / GSK3beta-Covalent Inhibitor Complex / Parkinson Disease |