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Title3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.
Journal, issue, pagesJ. Med. Chem., Vol. 62, Page 4606-4623, Year 2019
Publish dateJun 20, 2018 (structure data deposition date)
AuthorsJorda, R. / Havlicek, L. / Sturc, A. / Tuskova, D. / Daumova, L. / Alam, M. / Skerlova, J. / Nekardova, M. / Perina, M. / Pospisil, T. ...Jorda, R. / Havlicek, L. / Sturc, A. / Tuskova, D. / Daumova, L. / Alam, M. / Skerlova, J. / Nekardova, M. / Perina, M. / Pospisil, T. / Siroka, J. / Urbanek, L. / Pachl, P. / Rezacova, P. / Strnad, M. / Klener, P. / Krystof, V.
External linksJ. Med. Chem. / PubMed:30943029
MethodsX-ray diffraction
Resolution2.15 Å
Structure data

PDB-6gva:
CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR4455
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

Chemicals

ChemComp-FCQ:
5-(2-azanylethylsulfanyl)-3-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CL:
Unknown entry

ChemComp-BR:
BROMIDE ION

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-SGM:
MONOTHIOGLYCEROL

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / cyclin-dependent kinase / pyrazolo[4 / 3-d]pyrimidine

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