Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model.
Journal, issue, pages	J. Med. Chem., Vol. 61, Page 6724-6735, Year 2018
Publish date	Mar 15, 2018 (structure data deposition date)
Authors	Carcache, D.A. / Vulpetti, A. / Kallen, J. / Mattes, H. / Orain, D. / Stringer, R. / Vangrevelinghe, E. / Wolf, R.M. / Kaupmann, K. / Ottl, J. ...Carcache, D.A. / Vulpetti, A. / Kallen, J. / Mattes, H. / Orain, D. / Stringer, R. / Vangrevelinghe, E. / Wolf, R.M. / Kaupmann, K. / Ottl, J. / Dawson, J. / Cooke, N.G. / Hoegenauer, K. / Billich, A. / Wagner, J. / Guntermann, C. / Hintermann, S.
External links	J. Med. Chem. / PubMed:29990434
Methods	X-ray diffraction
Resolution	1.66 - 1.9 Å
Structure data	PDB-6fzu: RORGT (264-518;C455S) IN COMPLEX WITH THE FRAGMENT ("CPD-1") AND RIP140 PEPTIDE AT 1.80A Method: X-RAY DIFFRACTION / Resolution: 1.8 Å PDB-6g05: RORGT (264-518;C455S) IN COMPLEX WITH INVERSE AGONIST "CPD-2" AND RIP140 PEPTIDE AT 1.90A Method: X-RAY DIFFRACTION / Resolution: 1.9 Å PDB-6g07: RORGT (264-518;C455S) IN COMPLEX WITH INVERSE AGONIST "CPD-9" AND RIP140 PEPTIDE AT 1.66A Method: X-RAY DIFFRACTION / Resolution: 1.66 Å
Chemicals	ChemComp-EE8: ~{N}-(3-chloranyl-4-ethoxy-phenyl)ethanamide ChemComp-HOH: WATER ChemComp-EF5: 2-(4-ethylsulfonylphenyl)-~{N}-[4-phenyl-5-(phenylcarbonyl)-1,3-thiazol-2-yl]ethanamide ChemComp-EEZ: ~{N}-[5-chloranyl-6-[(1~{S})-1-phenylethoxy]pyridin-3-yl]-2-(4-ethylsulfonylphenyl)ethanamide
Source	homo sapiens (human)
Keywords	TRANSCRIPTION / FBS / NUCLEAR HORMONE RECEPTOR / LIGAND-BINDING DOMAIN / INVERSE AGONIST / SIGNALING PROTEIN / LIGAND BINDING DOMAIN