+Search query
-Structure paper
Title | Optimizing a Weakly Binding Fragment into a Potent ROR gamma t Inverse Agonist with Efficacy in an in Vivo Inflammation Model. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 61, Page 6724-6735, Year 2018 |
Publish date | Mar 15, 2018 (structure data deposition date) |
![]() | Carcache, D.A. / Vulpetti, A. / Kallen, J. / Mattes, H. / Orain, D. / Stringer, R. / Vangrevelinghe, E. / Wolf, R.M. / Kaupmann, K. / Ottl, J. ...Carcache, D.A. / Vulpetti, A. / Kallen, J. / Mattes, H. / Orain, D. / Stringer, R. / Vangrevelinghe, E. / Wolf, R.M. / Kaupmann, K. / Ottl, J. / Dawson, J. / Cooke, N.G. / Hoegenauer, K. / Billich, A. / Wagner, J. / Guntermann, C. / Hintermann, S. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.66 - 1.9 Å |
Structure data | ![]() PDB-6fzu: ![]() PDB-6g05: ![]() PDB-6g07: |
Chemicals | ![]() ChemComp-EE8: ![]() ChemComp-HOH: ![]() ChemComp-EF5: ![]() ChemComp-EEZ: |
Source |
|
![]() | TRANSCRIPTION / FBS / NUCLEAR HORMONE RECEPTOR / LIGAND-BINDING DOMAIN / INVERSE AGONIST / SIGNALING PROTEIN / LIGAND BINDING DOMAIN |