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Structure paper

TitleControl and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds.
Journal, issue, pagesFebs J., Vol. 286, Page 2135-2154, Year 2019
Publish dateDec 19, 2017 (structure data deposition date)
AuthorsPanmanee, J. / Bradley-Clarke, J. / Mato, J.M. / O'Neill, P.M. / Antonyuk, S.V. / Hasnain, S.S.
External linksFebs J. / PubMed:30776190
MethodsX-ray diffraction
Resolution1.35 - 2.7 Å
Structure data

PDB-6fbn:
Human Methionine Adenosyltransferase II mutant (Q113A)
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6fbo:
Human Methionine Adenosyltransferase II mutant (S114A) in I222 crystal form
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-6fbp:
Human Methionine Adenosyltransferase II mutant (S114A) in P22121 crystal form
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-6fcb:
Human Methionine Adenosyltransferase II mutant (P115G)
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6fcd:
Human Methionine Adenosyltransferase II mutant (R264A)
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-6g6r:
Human Methionine Adenosyltransferase II with SAMe and PPNP
Method: X-RAY DIFFRACTION / Resolution: 1.35 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SAM:
S-ADENOSYLMETHIONINE

ChemComp-PPK:
(DIPHOSPHONO)AMINOPHOSPHONIC ACID

ChemComp-MG:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-ADN:
ADENOSINE

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-ACT:
ACETATE ION

ChemComp-PPV:
PYROPHOSPHATE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE

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