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-Structure paper
Title | Selectively Targeting the Kinome-Conserved Lysine of PI3K delta as a General Approach to Covalent Kinase Inhibition. |
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Journal, issue, pages | J. Am. Chem. Soc., Vol. 140, Page 932-939, Year 2018 |
Publish date | Nov 13, 2017 (structure data deposition date) |
![]() | Dalton, S.E. / Dittus, L. / Thomas, D.A. / Convery, M.A. / Nunes, J. / Bush, J.T. / Evans, J.P. / Werner, T. / Bantscheff, M. / Murphy, J.A. / Campos, S. |
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Methods | X-ray diffraction |
Resolution | 2.04 - 2.2 Å |
Structure data | ![]() PDB-6eyz: ![]() PDB-6ez6: |
Chemicals | ![]() ChemComp-C5W: ![]() ChemComp-HOH: ![]() ChemComp-C5Z: |
Source |
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![]() | TRANSFERASE / Covalent inhibitor / kinase / drug discovery / complex |