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-Structure paper
Title | Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 4421-4435, Year 2018 |
Publish date | Sep 26, 2017 (structure data deposition date) |
![]() | Nuti, E. / Cuffaro, D. / Bernardini, E. / Camodeca, C. / Panelli, L. / Chaves, S. / Ciccone, L. / Tepshi, L. / Vera, L. / Orlandini, E. ...Nuti, E. / Cuffaro, D. / Bernardini, E. / Camodeca, C. / Panelli, L. / Chaves, S. / Ciccone, L. / Tepshi, L. / Vera, L. / Orlandini, E. / Nencetti, S. / Stura, E.A. / Santos, M.A. / Dive, V. / Rossello, A. |
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Methods | X-ray diffraction |
Resolution | 1.104 - 1.59 Å |
Structure data | ![]() PDB-6ekn: ![]() PDB-6ela: ![]() PDB-6enm: ![]() PDB-6eox: ![]() PDB-6esm: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-CA: ![]() ChemComp-B9N: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-B9Z: ![]() ChemComp-DIO: ![]() ChemComp-LPW: ![]() ChemComp-BKW: ![]() ChemComp-PZE: |
Source |
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![]() | HYDROLASE / metzincin / carboxylate inhibitor alternative zinc-binding groups |