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-Structure paper
Title | The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease. |
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Journal, issue, pages | EMBO Mol Med, Vol. 10, Year 2018 |
Publish date | Oct 13, 2017 (structure data deposition date) |
Authors | Neumann, U. / Ufer, M. / Jacobson, L.H. / Rouzade-Dominguez, M.L. / Huledal, G. / Kolly, C. / Luond, R.M. / Machauer, R. / Veenstra, S.J. / Hurth, K. ...Neumann, U. / Ufer, M. / Jacobson, L.H. / Rouzade-Dominguez, M.L. / Huledal, G. / Kolly, C. / Luond, R.M. / Machauer, R. / Veenstra, S.J. / Hurth, K. / Rueeger, H. / Tintelnot-Blomley, M. / Staufenbiel, M. / Shimshek, D.R. / Perrot, L. / Frieauff, W. / Dubost, V. / Schiller, H. / Vogg, B. / Beltz, K. / Avrameas, A. / Kretz, S. / Pezous, N. / Rondeau, J.M. / Beckmann, N. / Hartmann, A. / Vormfelde, S. / David, O.J. / Galli, B. / Ramos, R. / Graf, A. / Lopez Lopez, C. |
External links | EMBO Mol Med / PubMed:30224383 |
Methods | X-ray diffraction |
Resolution | 1.35 Å |
Structure data | PDB-6eqm: |
Chemicals | ChemComp-BUH: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / Structure-based drug design / Alzheimer's disease / aspartic acid proteinase |