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TitleTargeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease.
Journal, issue, pagesEur. J. Med. Chem., Vol. 226, Page 113847-113847, Year 2021
Publish dateOct 10, 2017 (structure data deposition date)
AuthorsCotrina, E.Y. / Santos, L.M. / Rivas, J. / Blasi, D. / Leite, J.P. / Liz, M.A. / Busquets, M.A. / Planas, A. / Prohens, R. / Gimeno, A. ...Cotrina, E.Y. / Santos, L.M. / Rivas, J. / Blasi, D. / Leite, J.P. / Liz, M.A. / Busquets, M.A. / Planas, A. / Prohens, R. / Gimeno, A. / Jimenez-Barbero, J. / Gales, L. / Llop, J. / Quintana, J. / Cardoso, I. / Arsequell, G.
External linksEur. J. Med. Chem. / PubMed:34555615
MethodsX-ray diffraction
Resolution1.38 Å
Structure data

PDB-6eoy:
Transthyretin in complex with 4-(1,3-Benzothiazol-2-yl)-2-methylaniline
Method: X-RAY DIFFRACTION / Resolution: 1.38 Å

Chemicals

ChemComp-BM8:
4-(1,3-benzothiazol-2-yl)-2-methyl-aniline

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / Transthyretin / amyloid / TTR amyloid inhibitor

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