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Title | Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK). |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 7273-7288, Year 2018 |
Publish date | Jul 18, 2018 (structure data deposition date) |
Authors | Ryder, T.F. / Calabrese, M.F. / Walker, G.S. / Cameron, K.O. / Reyes, A.R. / Borzilleri, K.A. / Delmore, J. / Miller, R. / Kurumbail, R.G. / Ward, J. ...Ryder, T.F. / Calabrese, M.F. / Walker, G.S. / Cameron, K.O. / Reyes, A.R. / Borzilleri, K.A. / Delmore, J. / Miller, R. / Kurumbail, R.G. / Ward, J. / Kung, D.W. / Brown, J.A. / Edmonds, D.J. / Eng, H. / Wolford, A.C. / Kalgutkar, A.S. |
External links | J. Med. Chem. / PubMed:30036059 |
Methods | X-ray diffraction |
Resolution | 3.27 - 3.4 Å |
Structure data | PDB-6e4t: PDB-6e4u: PDB-6e4w: |
Chemicals | ChemComp-HTV: ChemComp-STU: ChemComp-CL: ChemComp-AMP: ChemComp-ADP: ChemComp-SO4: ChemComp-HU7: ChemComp-HUG: |
Source |
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Keywords | TRANSFERASE / Kinase / AMPK / activator / allostery / TRANSFERASE-ACTIVATOR complex |