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-Structure paper
Title | Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 29, Page 2182-2188, Year 2019 |
Publish date | Jun 18, 2018 (structure data deposition date) |
Authors | Sasaki, T. / Gannam, Z.T.K. / Kudalkar, S.N. / Frey, K.M. / Lee, W.G. / Spasov, K.A. / Jorgensen, W.L. / Anderson, K.S. |
External links | Bioorg. Med. Chem. Lett. / PubMed:31281023 |
Methods | X-ray diffraction |
Resolution | 2.742 - 3.327 Å |
Structure data | PDB-6dtw: PDB-6dtx: |
Chemicals | ChemComp-H9Y: ChemComp-MG: ChemComp-SO4: ChemComp-HOH: ChemComp-GOL: |
Source |
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Keywords | HYDROLASE / TRANSFERASE/INHIBITOR / HIV-1 / reverse transcriptase / inhibitor / TRANSFERASE-INHIBITOR complex |