EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ジャーナル・号・ページ	ACS Infect Dis, Vol. 5, Page 316-325, Year 2019
掲載日	2018年5月18日 (構造データの登録日)
著者	Lockbaum, G.J. / Leidner, F. / Rusere, L.N. / Henes, M. / Kosovrasti, K. / Nachum, G.S. / Nalivaika, E.A. / Ali, A. / Yilmaz, N.K. / Schiffer, C.A.
リンク	ACS Infect Dis / PubMed:30543749
手法	X線回折
解像度	1.899 - 2.008 Å
構造データ	PDB-6dgx: Crystal structure of HIV-1 Protease NL4-3 WT in complex with darunavir 手法: X-RAY DIFFRACTION / 解像度: 2.001 Å PDB-6dgy: Crystal structure of HIV-1 Protease NL4-3 WT in complex with UMass1 手法: X-RAY DIFFRACTION / 解像度: 1.954 Å PDB-6dgz: Crystal structure of HIV-1 Protease NL4-3 WT in complex with UMass6 手法: X-RAY DIFFRACTION / 解像度: 1.994 Å PDB-6dh0: Crystal structure of HIV-1 Protease NL4-3 I84V Mutant in complex with darunavir 手法: X-RAY DIFFRACTION / 解像度: 1.899 Å PDB-6dh1: Crystal structure of HIV-1 Protease NL4-3 I84V Mutant in complex with UMass1 手法: X-RAY DIFFRACTION / 解像度: 1.971 Å PDB-6dh2: Crystal structure of HIV-1 Protease NL4-3 I84V Mutant in complex with UMass6 手法: X-RAY DIFFRACTION / 解像度: 1.978 Å PDB-6dh3: Crystal structure of HIV-1 Protease NL4-3 V82I Mutant in complex with darunavir 手法: X-RAY DIFFRACTION / 解像度: 1.908 Å PDB-6dh4: Crystal structure of HIV-1 Protease NL4-3 V82I Mutant in complex with UMass1 手法: X-RAY DIFFRACTION / 解像度: 1.943 Å PDB-6dh5: Crystal structure of HIV-1 Protease NL4-3 V82I Mutant in complex with UMass6 手法: X-RAY DIFFRACTION / 解像度: 2.008 Å PDB-6dh6: Crystal structure of HIV-1 Protease NL4-3 I50V Mutant in complex with darunavir 手法: X-RAY DIFFRACTION / 解像度: 1.97 Å PDB-6dh7: Crystal structure of HIV-1 Protease NL4-3 I50V Mutant in complex with UMass1 手法: X-RAY DIFFRACTION / 解像度: 1.997 Å PDB-6dh8: Crystal structure of HIV-1 Protease NL4-3 I50V Mutant in complex with UMass6 手法: X-RAY DIFFRACTION / 解像度: 1.951 Å
化合物	ChemComp-017: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE / ダルナビル / 薬剤, 抗レトロウイルス剤YM / ダルナビル ChemComp-SO4: SULFATE ION / 硫酸ジアニオン / 硫酸塩 ChemComp-HOH: WATER / 水 ChemComp-K13: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate ChemComp-A60*: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-ethylbutyl)amino}-1-benzyl-2-hydroxypropyl]carbamate
由来	human immunodeficiency virus 1 (ヒト免疫不全ウイルス)
キーワード	HYDROLASE/HYDROLASE INHIBITOR / HIV (ヒト免疫不全ウイルス) / Protease (プロテアーゼ) / NL4-3 / DRUG RESISTANCE (薬剤耐性) / PROTEASE INHIBITOR (プロテアーゼ阻害剤) / HYDROLASE INHIBITOR COMPLEX / HYDROLASE (加水分解酵素) / HYDROLASE-HYDROLASE INHIBITOR complex