+Search query
-Structure paper
Title | Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. |
---|---|
Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 29, Page 905-911, Year 2019 |
Publish date | May 14, 2018 (structure data deposition date) |
Authors | Zhang, B. / Kiefer, J.R. / Blake, R.A. / Chang, J.H. / Hartman, S. / Ingalla, E.R. / Kleinheinz, T. / Mody, V. / Nannini, M. / Ortwine, D.F. ...Zhang, B. / Kiefer, J.R. / Blake, R.A. / Chang, J.H. / Hartman, S. / Ingalla, E.R. / Kleinheinz, T. / Mody, V. / Nannini, M. / Ortwine, D.F. / Ran, Y. / Sambrone, A. / Sampath, D. / Vinogradova, M. / Zhong, Y. / Nwachukwu, J.C. / Nettles, K.W. / Lai, T. / Liao, J. / Zheng, X. / Chen, H. / Wang, X. / Liang, J. |
External links | Bioorg. Med. Chem. Lett. / PubMed:30732944 |
Methods | X-ray diffraction |
Resolution | 2.1 - 2.5 Å |
Structure data | PDB-6df6: PDB-6dfn: |
Chemicals | ChemComp-G8Y: ChemComp-GOL: ChemComp-HOH: ChemComp-G9J: ChemComp-NI: ChemComp-G91: |
Source |
|
Keywords | NUCLEAR PROTEIN / ERA / antagonist / inverse agonist / receptor / breast cancer / degrader / ligand / estrogen receptor |