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-Structure paper
| Title | MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology. |
|---|---|
| Journal, issue, pages | ACS Med Chem Lett, Vol. 9, Page 761-767, Year 2018 |
| Publish date | May 6, 2018 (structure data deposition date) |
 Authors | Boga, S.B. / Deng, Y. / Zhu, L. / Nan, Y. / Cooper, A.B. / Shipps Jr., G.W. / Doll, R. / Shih, N.Y. / Zhu, H. / Sun, R. ...Boga, S.B. / Deng, Y. / Zhu, L. / Nan, Y. / Cooper, A.B. / Shipps Jr., G.W. / Doll, R. / Shih, N.Y. / Zhu, H. / Sun, R. / Wang, T. / Paliwal, S. / Tsui, H.C. / Gao, X. / Yao, X. / Desai, J. / Wang, J. / Alhassan, A.B. / Kelly, J. / Patel, M. / Muppalla, K. / Gudipati, S. / Zhang, L.K. / Buevich, A. / Hesk, D. / Carr, D. / Dayananth, P. / Black, S. / Mei, H. / Cox, K. / Sherborne, B. / Hruza, A.W. / Xiao, L. / Jin, W. / Long, B. / Liu, G. / Taylor, S.A. / Kirschmeier, P. / Windsor, W.T. / Bishop, R. / Samatar, A.A. |
 External links | ACS Med Chem Lett / PubMed:30034615 |
| Methods | X-ray diffraction |
| Resolution | 1.45 Å |
| Structure data |  PDB-6dcg: |
| Chemicals |  ChemComp-SO4:  ChemComp-G67:  ChemComp-HOH: |
| Source |
|
 Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / KINASE INHIBITOR / KINASE SELECTIVITY / TRANSFERASE / SERINE/ THREONINE-PROTEIN KINASE / MAP KINASE / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX |
rattus norvegicus (Norway rat)